Do not judge the visit only by distance on a map. Consider the actual departure time, stops, shrine program, and when you must leave to return.
Fátima · YOUR QUESTION, ANSWERED
Can I go to Fátima as a day trip from Lisbon?
Yes. Fátima is about 130 km north of Lisbon, roughly 1.5 hours by road, and express buses from Lisbon Sete Rios take about 1.5 hours, so a day trip is practical. It offers limited time once transport is included, and it means missing the evening candlelight procession, which is held nightly in the main season. An overnight stay makes evening prayer and a less hurried return to the sanctuary easier.
Sources & further readingShrine of Fátima: official site
Official sources cover institutional information. Suggested pacing and itinerary choices are planning guidance. Check current arrangements for your travel dates.