The schedule is small because the shrine is a pilgrimage site within the Diocese of St. Augustine rather than a parish; Sunday obligation can also be met at the Cathedral Basilica downtown. Devotions on the grounds include the Chaplet of Divine Mercy Monday to Friday at 2:45 p.m. and the Seven Sorrows of Mary on Tuesday at 6:00 p.m. and Saturday at 10:00 a.m. The site does not state on its schedule page whether the noon Mass is in the small La Leche chapel or the larger Prince of Peace Church on the grounds; both are on the same walk, and the chapel holds only a few dozen people, so groups should ask when booking.
The gift shop and museum are open Monday to Saturday 10:00 a.m. to 4:00 p.m. and Sunday noon to 4:00 p.m. No admission fee is listed on the location page; parking is on site. The earlier page on the La Leche shrine tells its history, the 1565 landing Mass and the 2021 canonical coronation, and the Florida page places it with Orlando and Miami.
From Fort Myers it is about 4.5 hours by road, so a day visit means an early start to reach the 11:00 a.m. confessions and the noon Mass. The schedule can change for the September 8 anniversary of the first Mass and for diocesan events; the liturgical schedule page carries the current times.