From his death on September 23, 1968, until 2008 the saint rested in the crypt of the adjacent church of Santa Maria delle Grazie (1959); a public exposition in 2008 and 2009 preceded the transfer. The church seats about 6,500 inside and about 30,000 in the churchyard.

It is open daily from 7:00 a.m. to 7:00 p.m., and the crypt is step-free. Masses in the Church of St. Pio are at 7:30 a.m. (lower church), 10:00 a.m., and 11:30 a.m. daily, with further Masses in Santa Maria delle Grazie. Check the shrine's current schedule.